

Bone graft substitute optimized for orthopedic, trauma and spine surgery. The putty can be administered directly into the bone defect without mixing or preparation. It is composed of S53P4 bioactive glass bound by polyethylene glycols (PEG) and glycerol.
It is characterized by:
- Belonging to the third generation of biomaterials capable of regenerating, repairing and replacing damaged bone tissue. (1-2)
- Bioactive, biodegradable, (3) osteoconductive and osteostimulant*
- Highly malleable and resistant..
- Acts directly on the bone without fibrous interposition. (4)


Benefits:

Preserves bone geometry

Biocompatible engineering in natural processes (5)

With no loss of bone density (6)

Radiopaque

Indications:
- Filling, reconstruction and regeneration of bone defects
- Defects in bone cavities and hollows that are difficult to access.
Bibliographic references:
1- Vallet-Regí, M. (2011). Biocerámicas: evolución y aplicaciones. Investigación Química, 107(1), 28-35.
2- Välimäki, V., Aro, H. & Scand J. (2006).Molecular basis for action of bioactive glasses as bone graft substitute;95(2):95-102.
3- Saarenpää, I., Stoor, P., & Frantzén, J. (2017). BAG S53P4 putty as bone graft substitute – a rabbit model. Biomedical Glasses, 3(1), 30-40. https://doi.org/10.1515/bglass-2017-0003
4- Gallego, E., Medellín, H., De Lange, F. (2013). Análisis del desempeño estructural de andamios de hidroxiapatita utilizados en ingeniería tisular. Ingeniería Mecánica Tecnología y Desarrollo.
5- Tortolini P. & Rubio S. (2012). Diferentes alternativas de rellenos óseos. Avances en Periodoncia; 24 (3).
6- Saarenpää, I., Hirvonen, J., Rinne, J., & Frantzén, J. (2018). Novel Bioactive Glass Putty (S53P4) as Bone Graft Expander in Minimally Invasive Lumbosacral Interbody Fusion. Journal of Minimally Invasive Spine Surgery and Technique, 3(2), 52-58. https://doi.org/10.21182/jmisst.2018.00332

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