Bonalive glass is a bone substitute, repairer and regenerator. At the heart of its technology is S53P4 bioactive glass: an intelligent biomaterial consisting only of elements naturally occurring in the human body.


S53P4 bioactive glass is characterized by:

  1. Ability to firmly attach to living tissue and chemically bond to the surrounding bone, which naturally facilitates new bone formation 
  2. Bacterial growth inhibition properties (1-2-3-4-4-5), making it an effective tool in the filling of infected bone cavities
  3. It is gradually resorbed over time and replaced by bone (6). Postoperative follow-up of this process is possible due to its radiodense quality 
  4. Bonalive is not osteoinductive.


Bacterial growth inhibiting properties

Can be used close to the growth plate

Immediate biointegration (7)

It is biostimulant. (5)


  • Filling of bone cavities
  • Filling of bone cavities in the treatment of chronic osteomyelitis
  • Obliteration of the mastoid sinus


Slide Bonalive glass (0.5 - 0.8 mm) 5 cc Slide Bonalive vidrio (0.5-0.8mm) 10cc Slide Bonalvie vidrio (1.0-2.0mm) 5cc Slide Bonalive glass (1.0-2.0mm) 10cc

Bibliographic references:

  1. Drago, L., Vassena, C., Fenu, S., Vecchi, E. D., Signori, V., Francesco, R. D., & Romanò, C. L. (2014). In vitro antibiofilm activity of bioactive glass S53P4. Future Microbiology, 9(5), 593-601.
  2. Romanò, C. L., Logoluso, N., Meani, E., Romanò, D., De Vecchi, E., Vassena, C., & Drago, L. (2014). A comparative study of the use of bioactive glass S53P4 and antibiotic-loaded calcium-based bone substitutes in the treatment of chronic osteomyelitis. The Bone & Joint Journal, 96-B(6), 845-850.
  3. Välimäki, V.-V., & Aro, H. T. (2006). Molecular Basis for Action of Bioactive Glasses as Bone Graft Substitute. Scandinavian Journal of Surgery, 95(2), 95-102.
  4. Gunn, J.M., Rekola, J., Hirvonen, J, & Aho, A. (2013).Comparison of the osteoconductive properties of three particulate bone fillers in a rabbit model: Allograft, calcium carbonate (Biocoral®) and S53P4 bioactive glass. Acta Odontolologica Scandinavica; 71(5):1238-42.
  5. Virolainen, P., Heikkilä, J., Yli-Urpo, A., Vuorio, E. & Aro, HT. (1997). Histomorphometric and molecular biologic comparison of bioactive glass granules and autogenous bone grafts in augmentation of bone defect healing.J Biomed Mater Res;35A(1):9-17.


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