Bonalive glass is a bone substitute, repairer and regenerator. At the heart of its technology is S53P4 bioactive glass: an intelligent biomaterial consisting only of elements naturally occurring in the human body.
S53P4 bioactive glass is characterized by:
- Ability to firmly attach to living tissue and chemically bond to the surrounding bone, which naturally facilitates new bone formation
- Bacterial growth inhibition properties (1-2-3-4-4-5), making it an effective tool in the filling of infected bone cavities
- It is gradually resorbed over time and replaced by bone (6). Postoperative follow-up of this process is possible due to its radiodense quality
- Bonalive is not osteoinductive.
Bacterial growth inhibiting properties
Can be used close to the growth plate
Immediate biointegration (7)
It is biostimulant. (5)
- Filling of bone cavities
- Filling of bone cavities in the treatment of chronic osteomyelitis
- Obliteration of the mastoid sinus
- Drago, L., Vassena, C., Fenu, S., Vecchi, E. D., Signori, V., Francesco, R. D., & Romanò, C. L. (2014). In vitro antibiofilm activity of bioactive glass S53P4. Future Microbiology, 9(5), 593-601. https://doi.org/10.2217/fmb.14.20
- Romanò, C. L., Logoluso, N., Meani, E., Romanò, D., De Vecchi, E., Vassena, C., & Drago, L. (2014). A comparative study of the use of bioactive glass S53P4 and antibiotic-loaded calcium-based bone substitutes in the treatment of chronic osteomyelitis. The Bone & Joint Journal, 96-B(6), 845-850. https://doi.org/10.1302/0301-620x.96b6.33014
- Välimäki, V.-V., & Aro, H. T. (2006). Molecular Basis for Action of Bioactive Glasses as Bone Graft Substitute. Scandinavian Journal of Surgery, 95(2), 95-102. https://doi.org/10.1177/145749690609500204
- Gunn, J.M., Rekola, J., Hirvonen, J, & Aho, A. (2013).Comparison of the osteoconductive properties of three particulate bone fillers in a rabbit model: Allograft, calcium carbonate (Biocoral®) and S53P4 bioactive glass. Acta Odontolologica Scandinavica; 71(5):1238-42.
- Virolainen, P., Heikkilä, J., Yli-Urpo, A., Vuorio, E. & Aro, HT. (1997). Histomorphometric and molecular biologic comparison of bioactive glass granules and autogenous bone grafts in augmentation of bone defect healing.J Biomed Mater Res;35A(1):9-17.
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